For thousands of years, people have never given up the dream of immortality. We still have a desire to break the laws of nature. Many scientists are obsessed with research in this area. So what exactly is NMN? What are its effects and functions ?
What is NMN?
NMN is called β-Nicotinamide Mononucleotide. NMN has two isomers: α and β. Studies have found that only β-type NMN has biological activity. Structurally, the molecule is composed of nicotinamide, ribose, and phosphate.
Where is NMN?
NMN exists in some fruits, vegetables and poultry. It is a naturally occurring substance in the human body. It can be converted into NAD+, an important coenzyme related to human metabolism, in cells. NMN is one of the precursors of NAD+. In other words, the core effect of it is achieved through conversion into NAD+. As we age, the level of NAD+ in the human body gradually decreases.
The 2018 Aging Biology Research Compilation summarizes the two core mechanisms of human aging: Damage caused by oxidative stress (symptoms manifest as various diseases. Decreased levels of NAD+ in cells.
The main effects and functions of NMN
Delaying aging
Studies have shown that as we age, the synthesis of NAD+ in the human body gradually decreases, while the consumption of NAD gradually increases, so the total amount of NAD+ decreases. This decrease is strongly correlated with aging and disease. NMN is a metabolite inherent in the human body, which can be directly converted into the key coenzyme NAD+. Because NAD+ is an indispensable substance for nearly half of the metabolic activities of the human body, but it decreases rapidly with age. Therefore, taking NMN can increase the level of NAD+, thereby restoring the energy level and gene repair ability of cells to a youthful state, achieving the effect of delaying or even reversing aging.
Maintaining capillary regeneration capacity
As for the regenerative capacity of capillaries, as we age, the amount of NAD+ in our body decreases. Therefore, even if the effect of muscle growth is poor, the growth factors released are also less, and the capillaries become more fragile. Conversely, the body’s NAD is increased to maintain the regenerative capacity of capillaries. This improves cardiovascular and cerebrovascular health and stability. For example, increasing high-density lipoprotein, reducing low-density lipoprotein, anti-oxidation, reducing macrophage inflammatory response, reducing atherosclerotic plaque formation, stabilizing atherosclerotic plaques, reducing plaque rupture, and improving blood flow.
Repairing genetic genes (DNA)
The coenzyme (NAD+) is consumed as a substrate to generate the gene repair enzyme PARP1. At the same time, the PARP1 that has lost its activity due to binding to the protein DBC1 can be separated and restored to activity. PARP1 can recode the damaged gene according to the normal gene sequence to repair the gene. Studies have found that by regulating the level of NMN in the body, timely repairing damaged cells, slowing down cell mutation and aging, It is also possible to slow down human decline and reduce diseases, thereby achieving the purpose of anti-aging and gene repair.
Enhance human immunity
NMN has an important immunomodulatory effect. It can promote the production of antibodies by spleen cells, enhance the function of immune T cells, and stimulate the production of immunoglobulins. At the same time, NMN can also reduce muscle tissue oxidation, reduce lactic acid accumulation, muscle soreness after exercise, and enhance the body’s energy metabolism.
Improve skin condition
NMN awakens and repairs damaged skin cells, improves cell regeneration, enhances the endocrine system’s self-regulation, repairs the skin’s water retention, reduces wrinkles, and keeps the skin smooth and tender. It also improves cell circulation. After NMN acts on the face, the facial skin secretes collagen, hyaluronic acid, elastic fibers and other substances, making the skin firm, bright and shiny, and reducing pigmentation, while repairing sensitive skin damage caused by air pollution, ultraviolet radiation, etc.
Improve intestinal flora imbalance
More and more studies have found that the intestinal microbiota has a profound impact on the health and aging of the human body. Sleep deprivation can cause intestinal microbiota imbalance. NMN can help improve the imbalance, restore intestinal resistance, and activate body vitality.
Preventing diabetes
Insulin is the key to lowering blood sugar. After NMN increases the level of NAD+, it can stimulate insulin activity and enhance the decomposition of fat and polysaccharides in the body, thereby reducing the risk of diabetes.
Improve brain function
Alzheimer’s disease is one of the most devastating diseases of the elderly. Patients’ brains decline and eventually lose their memories and even forget their loved ones. Cognitive impairment is due to impaired blood flow to the brain, which is related to the aging of blood vessels. β-Nicotinamide Mononucleotide has been shown to increase blood flow to the brain and improve cognitive function of the brain. When blood vessels are blocked, it may cause a stroke, further damaging brain tissue. NMN has been shown to not only delay the onset of stroke, but also prevent stroke damage and improve cognitive.
NMN is suitable for people
Elderly people, used to help improve various geriatric diseases
Middle-aged people, eliminate or alleviate various sub-health problems, such as chronic fatigue, poor sleep, decreased vision, etc.
Stay up late, speed up the body’s recovery
Test takers, improve your stress resistance and keep a clear mind
Cancer patients, helping patients after radiotherapy and chemotherapy to repair genes, improve immunity, and speed up physical recovery
Bodybuilders, accelerate muscle growth
Best way to supplement NMN
NMN Capsules
Current human studies on NMN have almost exclusively used it supplements in capsule form. In many of these studies, NMN has been shown to increase blood NAD+ levels, indicating that it has strong bioavailability.
In some cases, the use of specialized capsules such as enteric-coated capsules can increase the bioavailability of compounds by taking advantage of the different pH levels of the gastrointestinal tract. The pH of our stomach is very acidic and is able to destabilize many compounds. However, pH-sensitive enteric-coated capsules can protect their contents by bypassing the stomach’s damage and dissolving in the intestines. In this way, enteric-coated capsules could increase the bioavailability of NMN, but this has not been extensively tested.
NMN powder
Powdered compounds are often packaged in capsules, which have the advantage of masking bad taste and preventing oral absorption. Powdered supplements can also be dissolved in water to avoid swallowing pills. This may be a viable option for NMN, given that it remains stable when dissolved in water.
In addition, many studies have shown that when NMN powder is added to the drinking water of mice, the level of NAD+ in the blood of mice can be increased, indicating that NMN powder has a certain bioavailability. However, compared with capsules, especially enteric-coated capsules, the powder is more likely to be destroyed by the gastric environment, resulting in a decrease in bioavailability.
FAQ
Can NMN be taken for a long time?
Supplementing with NMN will not affect the activity of various enzymes in the supplement synthesis pathway. Oral administration of NMN has no effect on the activity of various enzymes in the supplement synthesis pathway, such as NAMPT, PARP, NMNAT, etc. It directly changes the level of NAD+ in the body.
There are so many NAD+ precursors, why take NMN?
From the perspective of supplementing NAD+, the four types of precursors that can supplement the three metabolic cycles of NAD+ are niacin, tryptophan, nicotinamide and NMN/NR. Compared with other ways of supplementing NAD+, NMN bypasses the bottleneck of the rate-limiting enzyme NAMPT and can quickly supplement NAD+ in the body. It is the best and most scientific supplement method.
How is NMN absorbed quickly?
It is absorbed very quickly in the body and can quickly increase the level of NAD+ in the body:
Absorbed intact through the digestive system
Enters the blood within 2 to 3 minutes
Increase NMN content in tissues within 15 minutes
Rapidly increase NAD+ levels in blood, liver and other organs
Does NMN have any side effects?
NMN itself is a substance that exists naturally in the human body and is also found in many foods. It is purely natural and harmless.
Conclusion
In summary, the effects of NMN supplementation vary greatly from person to person, which may be related to differences in the intestinal microbiome, NAD+ synthetase activity, or NAD+ consuming enzymes (such as CD38). It is a powerful tool in the field of anti-aging, but it needs to be supplemented scientifically, combined with exercise, regular monitoring, and personalized dosage supplementation to maximize health benefits!
